Ethanol → Lamivudine

HRID 1046042Notes

Reaction equation

HRID 1046042 reaction equation
C(O)C.[CH2:4]1[S:8][C@H:7]([CH2:9][OH:10])[O:6][C@@H:5]1[N:11]1[C:16](=[O:17])[N:15]=[C:14]([NH2:18])[CH:13]=[CH:12]1.C([O-])(=O)C([O-])=O>C(N(CC)CC)C>[CH2:4]1[S:8][C@H:7]([CH2:9][OH:10])[O:6][C@@H:5]1[N:11]1[C:16](=[O:17])[N:15]=[C:14]([NH2:18])[CH:13]=[CH:12]1

Participants

4

Reactant 2

HCID 702EthanolHCID 86677229Lamivudine oxalate

Product 1

HCID 60825Lamivudine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 1000 ml of ethanol was added 120 g of Lamivudine oxalate (prepared by the method of the present invention). 60 ml of triethylamine was added at the temperature of 40˜45° C. for 0.5 hour, stirred at the same temperature for 4 hours, and centrifuged at room temperature. The product was dried under vacuum at the temperature of 40˜45° C. to obtain Lamivudine crystal.

Workup

  1. customprepared by the method of the present invention)
  2. customcentrifuged at room temperature
  3. customThe product was dried under vacuum at the temperature of 40˜45° C.

Sources & evidence

ORD record
ord-5ee8290bacac40029b7b8b691f483750
Source dataset
uspto-grants-2013_10
Patent number
US08569322B2

Reaction notes

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