Hydrochloric Acid → (R)-1-(3-Methyl-1,2,4-oxadiazol-5-yl)ethan-1-amine
Reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10]1[O:14][N:13]=[C:12]([CH3:15])[N:11]=1)[CH3:9])(C)(C)C.Cl>O1CCOCC1>[CH3:15][C:12]1[N:11]=[C:10]([C@H:8]([NH2:7])[CH3:9])[O:14][N:13]=1Participants
4
Procedure
To a solution of tert-butyl[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]carbamate (6.0 g, 26.4 mmol) in dioxane (40 mL) was added 4 M hydrochloric acid in dioxane (30 mL). The reaction mixture was stirred for 16 h. The solution was concentrated and dried by vacuum to give hydrochloride salt of (1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethanamine (5.1 g). 1H NMR (500 MHz, CD3OD): δ 490-4.83 (m, 1H); 2.41 (s, 3H); 1.72 (d, J=7.0 Hz, 3H). MS 128.2 (M+1).
Workup
- concentrationThe solution was concentrated
- customdried by vacuum
Sources & evidence
- ORD record
- ord-ecf0d4af030b4e15a6fab483224c764f
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08569512B2
Reaction notes
Loading…