Hydrochloric Acid → 1-(3-Chlorophenyl)pyrrolidin-3-amine dihydrochloride
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[ClH:21].O1CCOCC1>ClCCl>[ClH:1].[ClH:21].[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1Participants
5
Procedure
tert-Butyl 1-(3-chlorophenyl)pyrrolidin-3-ylcarbamate (120 mg, 0.404 mmol) in dichloromethane (0.5 ml) was treated with 4 molar hydrogen chloride in dioxane (1011 μL, 4.04 mmol) at ambient temperature in an open flask with rapid stirring. After 4 hours, the reaction was concentrated in vacuo to provide the di-hydrochloride salt of the title compound as a crude solid (122 mg, >100%).
Workup
- concentrationthe reaction was concentrated in vacuo
Sources & evidence
- ORD record
- ord-dcf6c86d683a45c4a4f4e58d82e59c77
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08569522B2
Reaction notes
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