HCID 117760182, compound → HCID 117759897, compound
Reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[CH:12]=[CH:11][C:10]=1[C:23]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][C:24]=1[F:31])C1C=CC=CC=1>C1COCC1.[Pd]>[F:31][C:24]1[CH:25]=[CH:26][C:27]([O:29][CH3:30])=[CH:28][C:23]=1[C:10]1[C:9]([OH:8])=[CH:14][C:13]([OH:15])=[CH:12][CH:11]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 2,4-bis(benzyloxy)-2′-fluoro-5′-methoxy-1,1′-biphenyl (23.9 g) in THF (300 mL) was added 10% palladium-activated carbon (9.60 g) and, under a hydrogen atmosphere, the mixture was stirred at room temperature for 2 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (21.8 g) as a colorless crude oil. This compound was used for the next step without further purification.