Hydrogen iodide → 4-Iodo-7H-pyrrolo(2,3-d)pyrimidine
Reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[IH:11]>>[I:11][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1Participants
3
Procedure
A mixture of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (673 mg, 4.41 mmol) and 7 mL of 57% hydriodic acid was stirred at room temperature for 16 hours. The solid was filtered off, suspended in 5 mL of water and brought to pH=8 with aqueous ammonia solution. The suspension was cooled down to 0° C. and the solid was filtered off, washed with cold water and dried to give the product to yield 970 mg of the product as a white powder. The product contains about 10% of the starting material.
Workup
- filtrationThe solid was filtered off
- temperatureThe suspension was cooled down to 0° C.
- filtrationthe solid was filtered off
- washwashed with cold water
- customdried
- customto give the product
Sources & evidence
- ORD record
- ord-0d0864e9b46e41a39b02051a462270d2
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394307B2
Reaction notes
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