Acetonitrile → N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethanamine

HRID 105685

Reaction equation

[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[CH3:22][C:23]#[N:24].[Cl:1][c:2]1[n:3][cH:4][c:5]([CH2:8][Cl:9])[cH:6][cH:7]1.[F:10][CH:11]([CH2:12][NH2:13])[F:14]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([CH2:8][NH:13][CH2:12][CH:11]([F:10])[F:14])[cH:6][cH:7]1

Participants

Reactant 4

HCID 6342Acetonitrile

HCID 8471Triethylamine

HCID 1362742,2-Difluoroethanamine

HCID 1554792-Chloro-5-(chloromethyl)pyridine

Product 1

HCID 44604123N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethanamine

Sources & evidence

ORD record: ord-79c97d8ff1f341d2a283ba7b2421d4ef
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Linked notes

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