3-Phenylprop-2-Enal → HCID 18672287, compound
Reaction equation
[CH:1](=O)[CH:2]=[CH:3][C:4]1C=CC=C[CH:5]=1.[C:11]([C:16]1([C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:20]([CH3:22])(C)[CH2:19][CH2:18][NH:17]1)([O:13][CH2:14][CH3:15])=[O:12]>>[CH2:26]([O:25][C:23]([C:16]1([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:20]([C:22]2[CH:5]=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH2:19][CH2:18][NH:17]1)=[O:24])[CH3:27]Participants
3
Procedure
Diethyl-3-phenylpyrrolidine-2,2-dicarboxylate was prepared from cinnamaldehyde (1.22 mL, 9.70 mmol) essentially according to the procedure described in U.S. Pat. No. 4,060,603 for the preparation of 2,2-dicarboethoxy-3,3-dimethyl-pyrrolidine. The resulting yellow oil was used in the next step without purification. LCMS RT=1.26 min. LCMS (M+H)=292.1.
Workup
- customThe resulting yellow oil was used in the next step without purification
Sources & evidence
- ORD record
- ord-a1c9227759bf4afdbcc940b2717876f0