Ammonium Chloride → HCID 178488575, compound

Temperature

-78 °C

4-Bromo-4′-methoxy-1,1′-biphenyl (1.95 g) was dissolved in THF (40 ml) and the mixture was cooled to −78° C. A solution (1.6 M; 5.5 ml) of n-butyllithium in hexane was added dropwise, and the mixture was stirred at −78° C. for 1 h. Then, a solution (10 ml) of 1-(1H-imidazol-4-yl)-2-methyl-1-propanone (335 mg) in THF was slowly added dropwise. The reaction mixture was heated from −78° C. to room temperature and saturated aqueous ammonium chloride solution was added to the reaction mixture. The mixture was extracted with ethyl acetate and the organic layer was dried and concentrated. The obtained residue was recrystallized from ethyl acetate to give the title compound (322 mg) as a colorless solid.

1. temperatureThe reaction mixture was heated from −78° C. to room temperature
2. extractionThe mixture was extracted with ethyl acetate
3. customthe organic layer was dried
4. concentrationconcentrated
5. customThe obtained residue was recrystallized from ethyl acetate

ORD record

ord-85164d6553684c5fa2859280b693ed18

Source dataset

uspto-grants-2003_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06518257B1