Ammonia → 1-(4-Methoxybenzo[d]thiazol-2-yl)urea

HRID 1060289

Reaction equation

HRID 1060289 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[NH2:13][C:14](N)=[O:15].N>O>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:14]([NH2:13])=[O:15])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 1176UreaHCID 216224-Methoxy-2-aminobenzothiazole

Product 1

HCID 222830361-(4-Methoxybenzo[d]thiazol-2-yl)urea

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-amino-4-methoxy-benzothiazole (330 mg, 1.83 mmol) and urea (1.1 g, 1.83 mmol) were heated together for 1 h at 170° C., with evolution of ammonia. After allowing to cool to r.t., water (10 ml) was added and the mixture was vigorously stirred. The solid was then filtered, washed with water (10 ml) followed by ethanol (10 ml) and dried at 60° C. under vaccum (0.05 mmHg). The title product was afforded as an off-white solid (300 mg, 73% yield), MS: m/e=223 (M+).

Workup

  1. filtrationThe solid was then filtered
  2. washwashed with water (10 ml)
  3. customdried at 60° C. under vaccum (0.05 mmHg)

Sources & evidence

ORD record
ord-5e47205b13d14e91a5d9d364e4b842d7
Source dataset
uspto-grants-2003_02
Patent number
US06521754B2

Linked notes

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