Tetrahydrofuran → Ethyl 4-amino-1-methyl-1H-indole-2-carboxylate

Reaction equation

O1CCCC1.[CH3:6][N:7]1[C:15]2[C:10](=[C:11]([N+:16]([O-])=O)[CH:12]=[CH:13][CH:14]=2)[CH:9]=[C:8]1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>[Pd].CO>[NH2:16][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[CH:9]=[C:8]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:7]2[CH3:6]

Participants

Procedure

In a solvent mixture of 50 ml of tetrahydrofuran and 50 ml of methanol was dissolved 1.37 g (5.52 mmol) of ethyl 1-methyl-4-nitro-2-indolecarboxylate. Thereafter 0.30 g of 10% palladium/carbon was added to the solution and catalytic hydrogenation was then conducted at ambient temperature under normal pressure. After completion of the reaction, the catalyst was filtered off and the filtrate was then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give 1.2 g (>99%) of ethyl 4-amino-1-methyl-2-indolecarboxylate.