4-(3-(Methylsulfonyl)phenyl)piperidine → 4-(3-Methanesulfonyl-phenyl)-1-butyl-piperidine
Reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3]>C(Cl)CCC>[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]2[CH2:16][CH2:15][N:14]([CH2:6][CH2:5][CH2:10][CH3:9])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Beginning with 4-(3-methanesulfonyl-phenyl)-piperidine and n-BuCl. MS m/z (rel. intensity, 70 eV) 295 (M+, 3), 252 (bp), 130 (5), 115 (3), 70 (8).
Sources & evidence
- ORD record
- ord-50b886da2324449eadf43ceee92a3daf
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06903120B2
Reaction notes
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