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Potassium Carbonate → HCID 15512465, compound

HRID 1071981
Notes
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Reaction equation

HRID 1071981 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11]Br)=[CH:2]1.[NH:13]1[CH2:18][CH2:17][CH:16]([NH:19]C(=O)OC(C)(C)C)[CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].S([O-])([O-])(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>O.C1(C)C=CC=CC=1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][N:13]2[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15][CH2:14]2)=[CH:2]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 7238334-(N-Boc-amino)piperidineHCID 11433187Bis(tetrabutylammonium) sulphateHCID 150754803-(2-bromoethyl)Benzofuran

Product 1

HCID 15512465HCID 15512465, compound

Reagents, catalysts & solvents 2

HCID 962
Water
Solvent
HCID 1140TolueneSolvent

Procedure

10 mmol of 2-(benzofuran-3-yl)-1-bromoethane, 9.62 mmol of tert-butyl 4-piperidyl-carbamate, 2.65 g of potassium carbonate and 0.65 g of tetrabutylammonium sulphate are added to 10 ml of toluene. After refluxing for 12 hours, the mixture is taken up in water. The organic phase is then washed with water, dried and then filtered. Evaporation under reduced pressure allows the expected product to be isolated.

Workup

  1. temperatureAfter refluxing for 12 hours
  2. washThe organic phase is then washed with water
  3. customdried
  4. filtrationfiltered
  5. customEvaporation under reduced pressure
  6. customto be isolated

Sources & evidence

ORD record
ord-33c732245465467fa3295518d835bccd
Source dataset
uspto-grants-2005_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06908922B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes