Potassium Carbonate → 1-(5-Bromo-1-benzofuran-2-yl)ethan-1-one
Reaction equation
[Br:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.Br[CH2:12][C:13](=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:13]([C:14]1[O:10][C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=2[CH:7]=1)(=[O:15])[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Bromo salicylaldehyde (10.05 g), bromo acetone (8.0 g) and potassium carbonate (13.80 g) were refluxed for 1 hr in 2-butanone (100 ml). 2-Butanone (ca. 50 ml) was evaporated and ice was added. The precipitate was collected by filtration and washed with water and hexane to give the objective compound (10.50 g).
Workup
- custom2-Butanone (ca. 50 ml) was evaporated
- additionice was added
- filtrationThe precipitate was collected by filtration
- washwashed with water and hexane
Sources & evidence
- ORD record
- ord-77f6a9a379cd467caaeb9aa6769a2fed
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06911469B2
Reaction notes
Loading…