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Methyl iodide → HCID 178503575, compound

HRID 1075163
Notes
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Reaction equation

HRID 1075163 reaction equation
[Cl:1][C:2]1[C:3](=[S:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH3:10]I>[H-].[Na+]>[CH3:10][S:9][C:3]1[C:2]([Cl:1])=[CH:7][NH:6][C:5](=[O:8])[N:4]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 53245582(1H)-pyrimidinone, 5-chloro-3,4-dihydro-4-thioxo-

Product 1

HCID 178503575HCID 178503575, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 24758Sodium hydrideSolvent

Procedure

5-Chloro-4-thiouracil (0.0027 mol) was dissolved in 1 M sodium hydride (3 ml) and methyl iodide (0.007 mol) added. The solution was stirred at room temperature for 3 hr. and the solid precipitate collected and recrystallised from water; yield 21%, m.p. 254° C.

Workup

  1. customand the solid precipitate collected
  2. customrecrystallised from water

Sources & evidence

ORD record
ord-f0e0bd5863d141bab154410e25b9eb9e
Source dataset
uspto-grants-1983_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04395406

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes