Iodoethane → HCID 178477361, compound
Reaction equation
[K].[F:2][C:3]1[C:4](=[S:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH2:11](I)[CH3:12]>CO>[CH2:11]([S:10][C:4]1[C:3]([F:2])=[CH:8][NH:7][C:6](=[O:9])[N:5]=1)[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The potassium salt of 5-fluoro-4-thiouracil (0.0065 mol) and ethyl iodide (0.014 mol) in methanol (40 ml) were stirred at room temperature for 6 days. The solutions were concentrated at reduced pressure and water (6 ml) added. The slowly precipitated product was recrystallised from water; yield 70%, m.p. 168° C.
Workup
- concentrationThe solutions were concentrated at reduced pressure and water (6 ml)
- additionadded
- customThe slowly precipitated product was recrystallised from water
Sources & evidence
- ORD record
- ord-efc4cf14311f45f3a108de1fe99d8dba
- Source dataset
- uspto-grants-1983_07
- Patent number
- US04395406
Reaction notes
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