Water → N-methyl-2H-3-isoquinolone

HRID 1075819

Reaction equation

HRID 1075819 reaction equation
S(O)(O)(=O)=O.[CH3:6][N:7]1[C:16](=[O:17])[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]2)=[CH:8]1.O.C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[CH3:6][N:7]1[C:16](=[O:17])[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]2)=[CH:8]1

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 21541268N-methyl-2H-3-isoquinolone sulfate

Product 1

HCID 12435498N-methyl-2H-3-isoquinolone

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

70 g. N-methyl-2H-3-isoquinolone sulfate are dissolved, under an atmosphere of nitrogen, in 900 ml. water. 75 g. sodium bicarbonate are added and the mixture is stirred with 500 ml. chloroform. By decantation, there is obtained a chloroform solution of N-methyl-2H-3-isoquinolone, which can be dried over anhydrous sodium sulfate and employed as such or concentrated for a further reaction.

Sources & evidence

ORD record
ord-c078a18486cf4a12876c27b719da7b99
Source dataset
uspto-grants-1976_05
Patent number
US03954771

Linked notes

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