Reaction equation
[NH2:1][CH:2]([CH3:5])[C:3]#[CH:4].[Cl:6][CH2:7][CH2:8][CH2:9][C:10](Cl)=[O:11]>>[Cl:6][CH2:7][CH2:8][CH2:9][C:10]([NH:1][CH:2]([CH3:5])[C:3]#[CH:4])=[O:11]Participants
3
Procedure
The compound 3-amino-1-butyne was treated with γ-chlorobutyryl chloride giving 3-(γ-chlorobutyramido)-1-butyne, m.p. 50°-51°C., which was ring-closed to N-(1-methylpropargyl)-pyrrolidin-2-one with the boiling point 71°C. at 0.8 mm Hg. Treatment of this product with formaldehyde and pyrrolidine yielded a reaction product which was isolated and purified as the sesquioxalate. It melted at 117°-119°C. after recrystallization from ethanol-ether.
Sources & evidence
- ORD record
- ord-71d4e05d43614317a9c43f16e27724fa
- Source dataset
- uspto-grants-1976_05
- Patent number
- US03959311
Linked notes
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