N-methyl-2-pyrrolidone → 6-chloro-N-methyl-2-morpholino-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine
Reaction equation
[C:9](=[O:10])([O-:11])[O-:12].[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1.[CH3:29][N:30]1[CH2:31][CH2:32][CH2:33][C:34]1=[O:35].[Cl:15][c:16]1[n:17][c:18]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[n:19][c:20]([Cl:22])[cH:21]1.[Cs+:13].[Cs+:14]>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1)[c:16]1[n:17][c:18]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[n:19][c:20]([Cl:22])[cH:21]1Participants
6
Sources & evidence
- ORD record
- ord-22592cea43774d2c985a1409c6e498be
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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