Pyrrolidine → HCID 19428538, compound

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[Cl:8][C:6]1[CH:7]=[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=[C:4]([NH:9][CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[N:5]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 19428516HCID 19428516, compound

Product 1

HCID 19428538HCID 19428538, compoundYield 96.7%

Procedure

The reaction of 4,6-dichloro-2-(2,2-dimethylpropylamino)pyrimidine with pyrrolidine as described in Example 12 gives the title product in a yield of 96.7%, m.p.: 147°-150° C.

Sources & evidence

ORD record: ord-528e7247d083497d975d8066b4b34ef9
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05550240

Reaction notes

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