Trifluoroacetic acid → 4-[(4-Pyrrolidinophenyloxy)methyl]piperidine
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[N:22]1([C:19]2[CH:18]=[CH:17][C:16]([O:15][CH2:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:21][CH:20]=2)[CH2:23][CH2:24][CH2:25][CH2:26]1Participants
3
Procedure
To 1-tert-butyloxycarbonyl-4-[(4-pyrrolidinophenyloxy)methyl]piperidine (0.55 g) obtained in Example 15 was added trifluoroacetic acid (2 ml), followed by stirring at room temperature for 10 minutes. The mixture was worked up according to the same manner as that described in Example 14 to obtain a fumarate and the fumarate was recrystallized from water/ethanol (1/2) to obtain 4-[(4-pyrrolidinophenyloxy)methyl]piperidine fumarate (0.5 g) as colorless crystals, m.p. 200°-205° C.
Sources & evidence
- ORD record
- ord-c27c8ec4dc7044f9943759b85d6e710c
- Source dataset