Acetone → N-[(2-hydroxy)ethyl]-2,4-dimethylthiazolium bromide
Reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH3:7])[N:6]=1.[O:8]1CCO[CH2:10][CH2:9]1.[Br:14]CCO.CC(C)=O>CCOCC>[Br-:14].[OH:8][CH2:9][CH2:10][N+:6]1[C:5]([CH3:7])=[CH:4][S:3][C:2]=1[CH3:1]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To the mixture of 2.4-dimethylthiazole (26.0 g) and dioxane (30 ml) was added 2-bromoethanol (40 g), and the resulting mixture was heated under reflux for 5 hours. To the mixture left standing at room temperature for about 0.5 hour was added acetone (150 ml) with stirring to give pale yellowish white solids. To the mixture was further added ether (150 ml), and the resulting powdery crystals were collected by filtration, washed with acetone and dried under reduced pressure.
Workup
- temperaturethe resulting mixture was heated
- temperatureunder reflux for 5 hours
- waitTo the mixture left
- customto give pale yellowish white solids
- filtrationthe resulting powdery crystals were collected by filtration
- washwashed with acetone
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-c4aaf398ecd4426f9a9669351438d1d8
- Source dataset
- uspto-grants-1996_12
- Patent number
- US05580904
Reaction notes
Loading…