Methyl iodide → 2,6-dichloro-7-methyl-7H-purine

HRID 1080671

Reaction equation

HRID 1080671 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.[C:12](=O)([O-])[O-].[K+].[K+].[CH3:18]I>CS(C)=O>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:12])[CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH3:18])=[C:4]([Cl:11])[N:3]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 53244122,6-Dichloropurine

Product 2

HCID 752812,6-dichloro-7-methyl-7H-purineHCID 17125532,6-dichloro-9-methyl-9H-purine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In a manner similar to Preparation A, 9.52 g of 2,6-dichloropurine, 7.65 g of potassium carbonate and 7.86 g of methyl iodide in 65 ml of dimethylsulfoxide gave 1.54 g of 2,6-dichloro-7-methylpurine and 4.7 g of 2,6-dichloro-9-methylpurine.

Sources & evidence

ORD record
ord-52955fdca6e54de68e1196fe9e2821aa
Source dataset
uspto-grants-1996_12
Patent number
US05583137

Linked notes

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