Cyclohexane → 3-Trifluoromethyl-2-(2-aminophenylthio)benzonitrile

HRID 1082067

Reaction equation

HRID 1082067 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[F:9][C:10]([F:21])([F:20])[C:11]1[C:12](F)=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15].C1CCCCC1>CN(C=O)C>[F:9][C:10]([F:20])([F:21])[C:11]1[C:12]([S:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH2:1])=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15]

Participants

5

Reactant 3

HCID 8078CyclohexaneHCID 87132-AminothiophenolHCID 5189742-Fluoro-3-(trifluoromethyl)benzonitrile

Product 1

HCID 199694453-Trifluoromethyl-2-(2-aminophenylthio)benzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using a procedure analagous to that of Example 3(a), 2-aminothiophenol (6.26 g, 50 mmol) was combined with 3-trifluoromethyl-2-fluorobenzonitrile (1 eq) in DMF solvent (50 ml) to give the title compound as a white solid from cyclohexane (10.41 g).

Sources & evidence

ORD record
ord-ae940f8d208346e8bf6e1fa1a5e2df22
Source dataset
uspto-grants-1996_12
Patent number
US05589474

Linked notes

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