Hydrochloric Acid → Methyl 4-methoxybenzimidate hydrochloride
Reaction equation
[C:1](#[N:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[ClH:11].[CH3:12][OH:13]>>[ClH:11].[CH3:12][O:13][C:1](=[NH:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1Participants
4
Procedure
25 g of anisonitril was dissolved in 250 ml of methanol. After saturation with hydrogen chloride gas under cooling in ice-water and stirring, the solution was stirred at room temperature for 15 hours. Then, methanol was evaporated in vacuo. Ether was added to the residue and the crystals were filtered off and dried. Whereby 35.9 g of the desired substance was obtained as white crystals. Melting point is 111° to 112° C. (Decomposition).
Workup
- stirringthe solution was stirred at room temperature for 15 hours
- customThen, methanol was evaporated in vacuo
- additionEther was added to the residue
- filtrationthe crystals were filtered off
- customdried
- customWhereby 35.9 g of the desired substance was obtained as white crystals
Sources & evidence
- ORD record
- ord-26c65a2b4cc14bbc9ffd179597e54f51
- Source dataset
- uspto-grants-1996_12
- Patent number
- US05589477
Reaction notes
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