Triethylamine → HCID 14719431, compound

HRID 1085375

Reaction equation

HRID 1085375 reaction equation
[CH2:1]([O:19][CH2:20][CH2:21][CH2:22][OH:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:24][S:25](Cl)(=[O:27])=[O:26].C(N(CC)CC)C>ClCCl>[CH3:24][S:25]([O:23][CH2:22][CH2:21][CH2:20][O:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])(=[O:27])=[O:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 5553033-Octadecyloxypropanol

Product 1

HCID 14719431HCID 14719431, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In dichloromethane (50 ml) is dissolved 3-(octadecyloxy)propanol (8.0 g). To the solution are added, under ice-cooling, methanesulfonyl chloride (4.18 g) and triethylamine (5.1 ml). The mixture is stirred at room temperature for one hour. The reaction mixture is washed with water and an aqueous solution of sodium hydrogencarbonate, successively, and then dried. The solvent is distilled off under reduced pressure to give the above-titled compound (9.7 g).

Workup

  1. additionTo the solution are added, under ice-
  2. temperaturecooling
  3. washThe reaction mixture is washed with water
  4. dry with materialan aqueous solution of sodium hydrogencarbonate, successively, and then dried
  5. distillationThe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-5231a62ac23d4fbd8898c56889ce6997
Source dataset
uspto-grants-1991_04
Patent number
US05008454

Linked notes

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