Water → 1,2-Bis(3,4-dimethoxyphenyl)ethanone

HRID 1087287

Reaction equation

HRID 1087287 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12]([OH:14])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].O.[C:16]1([O:24][CH3:25])[C:17](=[CH:20][CH:21]=[CH:22][CH:23]=1)[O:18][CH3:19]>>[CH3:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:11][C:12]([C:22]2[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:16]([O:24][CH3:25])[CH:23]=2)=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 3

HCID 962WaterHCID 7043VeratroleHCID 7139(3,4-Dimethoxyphenyl)acetic acid

Product 1

HCID 2311111,2-Bis(3,4-dimethoxyphenyl)ethanoneYield 60%

Procedure

A warm solution of 3,4-dimethoxyphenylacetic acid (10 g) in veratrole (15 ml) was added to 200 g of polyphosphoric acid (PPA). After 24 hrs. at room temperature the acid mixture was added to cold water (800 ml) and the product was collected and recrystallized from aqueous ethanol. The recrystallized intermediate (9.5 g, 60% yield) had a melting point of 104°-105°.

Workup

  1. customthe product was collected
  2. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-39ca3b0eaeec40169d68941347309b1a
Source dataset
uspto-grants-1991_07
Patent number
US05034544

Linked notes

Loading…