Dichloromethane → HCID 15058496, compound

HRID 1087318

Reaction equation

HRID 1087318 reaction equation
Br[CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.C(Cl)Cl>CO>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([N:19]1[CH2:20][CH2:21][N:16]([CH3:15])[CH2:17][CH2:18]1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:7]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 531671-MethylpiperazineHCID 4737529Ethyl 2-bromo-3-phenylpropanoate

Product 1

HCID 15058496HCID 15058496, compoundYield 14.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

EThyl 2-bromo-3-phenylpropionate (1.95 g) was treated with 3.05 g N-methylpiperazine as described in Example 95 to afford 0.30 g pure product after chromatography (9:1 CH2Cl2 :MeOH). NMR (300 MHz, CDCl3) delta 1.10 (d, J=7 Hz, 3H), 2.26 (s, 3H), 3.37 (m, 1H), 4.00 (m, 2H).

Sources & evidence

ORD record
ord-199580f190c84b378ea700c2e98da722
Source dataset
uspto-grants-1991_07
Patent number
US05034376

Linked notes

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