Hydrochloric Acid → Imidazo[1,2-a]pyridin-8-ol--hydrogen chloride (1/1)

Reaction equation

C([O:8][C:9]1[C:10]2[N:11]([CH:15]=[CH:16][N:17]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[ClH:18]>>[ClH:18].[OH:8][C:9]1[C:10]2[N:11]([CH:15]=[CH:16][N:17]=2)[CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 134329748-(Benzyloxy)imidazo[1,2-a]pyridine

Product 1

HCID 13037245Imidazo[1,2-a]pyridin-8-ol--hydrogen chloride (1/1)

Procedure

In 80 ml of concentrated hydrochloric acid is dissolved 5 g of 8-benzyloxyimidazo[1,2-a]pyridine, and the solution is stirred at room temperature for 24 hours and then concentrated. After addition of 1-butanol, water is azeotropically removed by distillation, and the residue is crystallized from diethyl ether to give 3.8 g of the above-identified compound.

Workup

concentrationconcentrated
additionAfter addition of 1-butanol, water
customis azeotropically removed by distillation
customthe residue is crystallized from diethyl ether

Sources & evidence

ORD record: ord-bd6126c91c904e49801df86856223c33
Source dataset: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04962100

Reaction notes

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