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Hydrochloric Acid → HCID 178478575, compound

HRID 1090233
Notes
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Reaction equation

HRID 1090233 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:14][C:15]1[C:16]2[C:17]3[C:21](=[C:22]([Cl:24])[CH:23]=1)[N:20]=[C:19](S)[C:18]=3[CH:26]=[CH:27][CH:28]=2.C(O)C.[ClH:32]>CC(C)=O>[ClH:14].[ClH:32].[Cl:14][C:15]1[C:16]2[C:17]3[C:21](=[C:22]([Cl:24])[CH:23]=1)[N:20]=[C:19]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[C:18]=3[CH:26]=[CH:27][CH:28]=2
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 139528607-(1H-imidazol-1-yl)heptan-1-amineHCID 178527805HCID 178527805, compound

Product 1

HCID 178478575HCID 178478575, compound

Reagents, catalysts & solvents 1

HCID 180Acetone
Solvent

Procedure

The free base of the title compound was prepared by the method of Example 55, utilizing 5.4 grams of 7-(1H-imidazol-1-yl)heptanamine, 7.6 grams of 6,8-dichlorobenz(cd)indol-2-thiol, 9.5 grams of mercuric acetate, and 500 ml of ethanol. A solution of 2.5 grams of the free base in 100 ml warm ethanol was treated with 30 ml of 2.3 N ethanolic hydrogen chloride. The resultant mixture was taken to dryness in vacuo, and the residual syrup boiled up in 400 ml of acetone. Cooling at room temperature gave 1.9 grams of the title compound mp 198° C.-201° C.

Workup

  1. customThe free base of the title compound was prepared by the method of Example 55

Sources & evidence

ORD record
ord-17f8c054f38743c9af20ff52eab3d152
Source dataset
uspto-grants-1992_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05081131

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes