Octanoic Acid → N-[3-(1H-Imidazol-1-yl)propyl]octanamide
Reaction equation
[C:1]([OH:10])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[N:11]1([CH2:16][CH2:17][CH2:18][NH2:19])[CH:15]=[CH:14][N:13]=[CH:12]1>O1CCCC1>[N:11]1([CH2:16][CH2:17][CH2:18][NH:19][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:15]=[CH:14][N:13]=[CH:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The requisite starting amine was prepared as follows: reaction of n-octanoic acid and 1,1'-carbonyldi(1-imidazole) in tetrahydrofuran solution with 3-(1H-imidazol-1-yl)propanamine gave N-3-(1H-imidazolyl) propyl-n-octanamide, which upon reduction with BH3 in tetrahydrofuran solution gave N-(3-(1H-imidazol-1-yl) propyl-N-(n-octyl))amine.