Hydrochloric Acid → HCID 178486502, compound

HRID 1091517Notes

Reaction equation

HRID 1091517 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:25][CH3:26])=[CH:5][C:6]2[C:7]3[N:8]([CH2:22][CH2:23][N:24]=3)[C:9](/[CH:13]=[C:14](/[C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)\[OH:15])=[N:10][C:11]=2[CH:12]=1.[ClH:27]>O1CCOCC1>[ClH:27].[CH3:1][O:2][C:3]1[C:4]([O:25][CH3:26])=[CH:5][C:6]2[C:7]3[N:8]([CH2:22][CH2:23][N:24]=3)[C:9](/[CH:13]=[C:14](/[C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)\[OH:15])=[N:10][C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486501HCID 178486501, compound

Product 1

HCID 178486502HCID 178486502, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of (Z)-2-(8,9-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-1-(3-pyridinyl)ethenol (16.8 mg, 0.05 mmol)) in dioxane (15 ml) at room temperature was added aqueous 6N HCl solution (0.05 ml). After being stirred for 30 minutes, the mixture was dried under reduced pressure to give (Z)-2-(8,9-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-1-(3-pyridinyl)ethenol hydrochloride (18.5 mg, quantitative) as a yellow solid.

Workup

  1. customthe mixture was dried under reduced pressure

Sources & evidence

ORD record
ord-4c26e1bad9fc42829ff83b4561a516e3
Source dataset
uspto-grants-2012_03
Patent number
US08129386B2

Reaction notes

Loading…