Triethylamine → HCID 178526855, compound
Reaction equation
[Cl:1][C:2]1[NH:3][C:4](I)=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.C(N(CC)CC)C>C(O)C.[OH-].[Pd+2].[OH-].[C]>[Cl:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
2-Chloro-5-iodo-4-nitroimidazole (273 mg) was dissolved in ethanol (5 ml), then triethylamine (420 μl) and 20% palladium hydroxide-carbon (27 mg) were added, the reaction mixture was subjected to hydrogenation at a room temperature under normal pressure for 5 hours, there was obtained 2-chloro-4-nitroimidazole (123 mg, yield: 83.4%) as colorless solid product.
Sources & evidence
- ORD record
- ord-5cb95f15bc784532852be9a36611a733
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08129544B2
Reaction notes
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