1-Propanol → HCID 178504130, compound

Reaction equation

N=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[NH:8][C:9]([N:11]1C=CN=C1)=[S:10].Cl[CH2:17][C:18]1[N:19](C)[CH:20]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:22]=1.[CH2:30](O)CC>>[CH3:30][SH:10]([CH2:17][C:18]1[NH:19][CH:20]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:22]=1)[C:9]1[N:11]=[C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][N:3]2[N:8]=1

Participants

Reactant 3

HCID 10311-Propanol

HCID 15334493Imidazole-1-carbothioic acid (2-imino-2H-pyridin-1-yl)-amide

HCID 591512282-Chloromethyl-1-methyl-4-phenyl-1H-imidazole

Product 1

HCID 178504130HCID 178504130, compoundYield 62%

Procedure

An adaptation of the method described in WO 96/01826 was used. Imidazole-1-carbothioic acid (2-imino-2H-pyridin-1-yl)-amide (200 mg, 1.37 mmol) and 2-chloromethyl-1-methyl-4-phenyl-1H-imidazole 6 (300 mg, 1.46 mmol) were dissolved in 1-propanol (25 mL) and the mixture was heated to reflux for 2 hours. The solvent was removed under reduced pressure and the residue dissolved in dichloromethane. The solution was washed with water and the organic layer was dried over Na2SO4 and concentrated. The residue was purified by chromatography on silica gel to afford the title compound (273 mg, 62%) as a yellow solid. LC-MS: m/z=322.1 (MH+), tR=2.29 min, method B.