Reaction equation
[CH2:1]([C:3]1[S:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1)[CH3:2].S1C=CC=[C:12]1C(O)=O.ICCC>>[CH2:1]([C:3]1[S:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1)[CH2:2][CH3:12]Participants
4
Procedure
The title compound is prepared in analogy to 5-ethyl-thiophene-2-carboxylic acid starting from 2-thiophenecarboxylic acid and 1-iodopropane; LC-MS: tR=0.87 min, 1H NMR (CDCl3): δ 0.99 (t, J=7.0 Hz, 3H), 1.74 (hex, J=7.3 Hz, 2H), 2.83 (t, J=7.6 Hz, 2H), 6.82 (d, J=3.5 Hz, 1H), 7.73 (d, J=3.8 Hz, 1H).
Sources & evidence
- ORD record
- ord-e4e5214f5429489399cb1863ff9dfa15
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08133910B2
Linked notes
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