Ethyl Acetate → 6-(3-hydroxypropyl)-6-isopropyl-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one

Reaction equation

[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([CH:29]([CH3:31])[CH3:30])OC(=O)[N:8]([C@H:12]([C:14]2[CH:19]=[CH:18][C:17](B3OC(C)(C)C(C)(C)O3)=[CH:16][CH:15]=2)[CH3:13])[CH2:7][CH2:6]1.CC(C)(C[C@@]1(C2C=CC=CC=2)OC(=O)N([C@H](C2C=CC([C:52]3[CH:57]=[CH:56][NH:55][C:54](=[O:58])[CH:53]=3)=CC=2)C)CC1)C#N.[C:66]([O-:69])([O-])=[O:67].[Cs+].[Cs+].[CH3:72]COC(C)=O>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([CH:29]([CH3:30])[CH3:31])[O:69][C:66](=[O:67])[N:8]([C@H:12]([C:14]2[CH:15]=[CH:16][C:17]([C:52]3[CH:57]=[CH:56][N:55]([CH3:72])[C:54](=[O:58])[CH:53]=3)=[CH:18][CH:19]=2)[CH3:13])[CH2:7][CH2:6]1