Ethylene Glycol → 6-Chloro-2-[[4-[5-(trifluoromethyl)pyridin-2-yl]-1-piperazinyl]methyl]imidazo[1,2-a]pyridine

HRID 109791

Reaction equation

HRID 109791 reaction equation
[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Cl:17][c:18]1[cH:19][cH:20][c:21]2[n:22]([cH:23]1)[cH:24][c:25]([CH2:27][Cl:28])[n:26]2.[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[n:7][cH:8]1)([F:15])[F:16].[OH:36][CH2:37][CH2:38][OH:39]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:27][c:25]3[cH:24][n:22]4[c:21]([cH:20][cH:19][c:18]([Cl:17])[cH:23]4)[n:26]3)[CH2:13][CH2:14]2)[n:7][cH:8]1)([F:15])[F:16]

Participants

5

Reactant 4

HCID 174Ethylene GlycolHCID 8471TriethylamineHCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazineHCID 48683896-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine

Product 1

HCID 193671176-Chloro-2-[[4-[5-(trifluoromethyl)pyridin-2-yl]-1-piperazinyl]methyl]imidazo[1,2-a]pyridine

Sources & evidence

ORD record
ord-e97fb1479fb746e0856bfeff3cdc61bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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