HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester → (6R,8S)-3-(allyl-benzyloxycarbonyl-amino)-8-tert-butoxycarbonylmethyl-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester | HCID 69600731 | — |
| Reactant | (6S,8R)-3-(allyl-benzyloxycarbonyl-amino)-8-azido-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid | HCID 86590672 | — |
| Product | (6R,8S)-3-(allyl-benzyloxycarbonyl-amino)-8-tert-butoxycarbonylmethyl-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid | HCID 69600615 | 89% |
Reaction Steps
According to the procedure for the preparation of 18f, intermediate 38b (413.9 mg, 0.62 mmol) was deprotected to afford 273.9 mg (89%) of intermediate 38c. MS (ESI) 498.4 (M+H+), 496.2 (M−H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094783B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-f48e92db5f75411fa21ca293595467aa |
| Source note | uspto-grants-2006_08 |