Tetrahydrofuran → (1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol

HRID 110269

Reaction equation

HRID 110269 reaction equation
[CH2:19]([Li:20])[CH2:21][CH2:22][CH3:23].[CH3:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].[CH3:30][S:31][c:32]1[c:33]([C:40]([F:41])([F:42])[F:43])[cH:34][c:35]([CH:36]=[O:37])[cH:38][cH:39]1.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[c:1]1([S:7](=[O:8])(=[O:9])[n:10]2[cH:11][cH:12][c:13]3[c:14]2[n:15][cH:16][cH:17][cH:18]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([S:7](=[O:8])(=[O:9])[n:10]2[c:11]([CH:36]([c:35]3[cH:34][c:33]([C:40]([F:41])([F:42])[F:43])[c:32]([S:31][CH3:30])[cH:39][cH:38]3)[OH:37])[cH:12][c:13]3[c:14]2[n:15][cH:16][cH:17][cH:18]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 8520781-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridineHCID 59234010Benzaldehyde, 4-(methylthio)-3-(trifluoromethyl)-HCID 178418339Butyllithium

Product 1

HCID 67229160(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol

Sources & evidence

ORD record
ord-25c897c90a6d46cea68f064bd09a2db7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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