Phenylacetonitrile → Phenyl(pyridin-3-yl)acetonitrile

HRID 1107431Notes

Reaction equation

HRID 1107431 reaction equation
Cl[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH2:8]([C:15]#[N:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[K+]>CN(C=O)C>[C:9]1([CH:8]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[C:15]#[N:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 8794PhenylacetonitrileHCID 122873-ChloropyridineHCID 23665647Potassium tert-butoxide

Product 1

HCID 270956Phenyl(pyridin-3-yl)acetonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound was prepared substantially in accordance with the procedure in Example 12A, using 3-chloropyridine (9.5 ml, 100 mmol), benzyl cyanide (11.6 ml, 100 mmol) and potassium t-butoxide (22.4 g, 200 mmol) in 200 ml of DMF.

Workup

  1. customThe compound was prepared substantially in accordance with the procedure in Example 12A

Sources & evidence

ORD record
ord-812c456818834fe4a33fa148a127b9cc
Source dataset
uspto-grants-2000_05
Patent number
US06060484

Reaction notes

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