Phenylacetonitrile → HCID 356429, compound
Reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:12]([C:19]#[N:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.CC(C)([O-])C.[K+]>CN(C=O)C>[C:13]1([CH:12]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[C:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The compound was prepared substantially in accordance with the procedure detailed in Example 12A, using 2-chloroquinoline (5.0 g, 30.6 mmol), benzyl cyanide (3.5 ml, 30.6 mmol) and potassium t-butoxide (6.87 g, 61.2 mmol) in 40 ml of DMF.
Workup
- customThe compound was prepared substantially in accordance with the procedure
Sources & evidence
- ORD record
- ord-b1bb1dafb0fb46bcabe4a51a2b2fe649
- Source dataset
- uspto-grants-2000_05
- Patent number
- US06060484
Reaction notes
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