Hydrochloric Acid → 5-Bromo-3-phenylbenzo[b]thiophene-2-carboxylic acid
Reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([C:15]([O:17]C)=[O:16])=[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:4]=2[CH:3]=1.Cl>CO.[OH-].[Na+]>[Br:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([C:15]([OH:17])=[O:16])=[C:8]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:4]=2[CH:3]=1Participants
5
Procedure
Heat three grams of methyl 5-bromo-3-phenylbenzo[b]thiophene-2-carboxylate in a mixture of 50 ml of methanol and 30 ml of 10% sodium hydroxide, under reflux for 1 hour. Add concentrated hydrochloric acid to yield the title compound as a precipitate. Recrystallize from benzene; m.p. 265°-266°.
Workup
- temperatureunder reflux for 1 hour
Sources & evidence
- ORD record
- ord-d677a14a9a5e40c6bdb194f4df9a72be
- Source dataset
- uspto-grants-1978_10
- Patent number
- US04122034
Reaction notes
Loading…