Pivalic acid → Apovincamine pivalate

HRID 1112362

Reaction equation

HRID 1112362 reaction equation
[C:1]([OH:7])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[CH3:8][CH2:9][C@:10]12[CH:26]=[C:25]([C:27]([O:29][CH3:30])=[O:28])[N:24]3[C:16]4=[C:17]([CH2:31][CH2:32][N:14]([C@@H:15]14)[CH2:13][CH2:12][CH2:11]2)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=13>O>[CH3:8][CH2:9][C@:10]12[CH:26]=[C:25]([C:27]([O:29][CH3:30])=[O:28])[N:24]3[C:16]4=[C:17]([CH2:31][CH2:32][N:14]([C@@H:15]14)[CH2:13][CH2:12][CH2:11]2)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=13.[C:1]([O-:7])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 6417Pivalic acidHCID 71204Apovincamine2×

Product 1

HCID 86736086Apovincamine pivalate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the method of the preceding example, 4 g of the salt are prepared starting from 1.02 g of pivalic acid and 3.36 g of apovincamine. The product has melting point of 110° C., is insoluble in water and soluble in alcohol; the apovincamine content thereof is 73.8%.

Workup

  1. customare prepared

Sources & evidence

ORD record
ord-c703c6e470624b778d0f511a37650509
Source dataset
uspto-grants-1978_10
Patent number
US04122179

Linked notes

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