Tetrahydrofuran → 4-Benzyloxy-1-{2-oxo-2-[3-(2,2,2-trifluoro-acetyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-ethyl}-1H-pyridin-2-one

HRID 1113686

Reaction equation

HRID 1113686 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](=[O:15])[nH:12][cH:13][cH:14]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH2:43]([N+:44]([CH2:45][CH2:46][CH2:47][CH3:48])([CH2:49][CH2:50][CH2:51][CH3:52])[CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH3:59].[Cl:16][CH2:17][C:18](=[O:19])[c:20]1[cH:21][c:22]2[c:23]([cH:35][cH:36]1)[CH2:24][CH2:25][N:26]([C:29]([C:30]([F:31])([F:32])[F:33])=[O:34])[CH2:27][CH2:28]2.[I-:42]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](=[O:15])[n:12]([CH2:17][C:18](=[O:19])[c:20]2[cH:21][c:22]3[c:23]([cH:35][cH:36]2)[CH2:24][CH2:25][N:26]([C:29]([C:30]([F:31])([F:32])[F:33])=[O:34])[CH2:27][CH2:28]3)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 30165Iodide IonHCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 592398392-chloro-1-[3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]ethanone

Product 1

HCID 580428744-Benzyloxy-1-{2-oxo-2-[3-(2,2,2-trifluoro-acetyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-ethyl}-1H-pyridin-2-one

Sources & evidence

ORD record
ord-193a828366e741ea87074365405bd0ed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Linked notes

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