Ethanol → Ethyl 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-(1-piperazinyl)nicotinoyl]acetate

Reaction equation

[CH2:1]1[CH2:2][NH:3][CH2:4][CH2:5][NH:6]1.[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37].[CH3:38][CH2:39][OH:40].[Cl:7][c:8]1[n:9][c:10]([NH:23][c:24]2[c:25]([F:31])[cH:26][c:27]([F:30])[cH:28][cH:29]2)[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]1[F:22]>>[CH2:1]1[CH2:2][N:3]([c:8]2[n:9][c:10]([NH:23][c:24]3[c:25]([F:31])[cH:26][c:27]([F:30])[cH:28][cH:29]3)[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]2[F:22])[CH2:4][CH2:5][NH:6]1