Acetic Acid → 1H-Pyrrolo[2,3-B]pyridin-5-amine, 1-[tris(1-methylethyl)silyl]-

Reaction equation

[CH3:22][CH2:23][O:24][C:25](=[O:26])[CH3:27].[CH3:28][C:29](=[O:30])[OH:31].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][c:7]1[NH2:8])[n:9]([Si:12]([CH:13]([CH3:14])[CH3:15])([CH:16]([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[cH:10][cH:11]2.[Zn:32]>>[cH:2]1[c:3]2[c:4]([n:5][cH:6][c:7]1[NH2:8])[n:9]([Si:12]([CH:13]([CH3:14])[CH3:15])([CH:16]([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[cH:10][cH:11]2

Participants

Reactant 4

HCID 176Acetic Acid

HCID 8857Ethyl Acetate

HCID 23994Zinc

HCID 222736624-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-amine

Product 1

HCID 222736141H-Pyrrolo[2,3-B]pyridin-5-amine, 1-[tris(1-methylethyl)silyl]-

Sources & evidence

ORD record: ord-4e683db2da314addaf30d7197ac299a0
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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