Sodium Ion → 2-bromo-4-(cyclopropylmethyl)pyrido[2,3-b]pyrazin-3(4H)-one

Reaction equation

[CH:1]1([CH2:4][n:5]2[c:6]3[c:7]([n:8][c:9]([OH:12])[c:10]2=[O:11])[cH:13][cH:14][cH:15][n:16]3)[CH2:2][CH2:3]1.[Cl:28][CH:29]([Cl:30])[CH3:31].[Na+:22].[Na+:23].[O-:24][C:25](=[O:26])[O-:27].[P:17]([Br:18])([Br:19])([Br:20])=[O:21]>>[CH:1]1([CH2:4][n:5]2[c:6]3[c:7]([n:8][c:9]([Br:19])[c:10]2=[O:11])[cH:13][cH:14][cH:15][n:16]3)[CH2:2][CH2:3]1

Participants

Reactant 5

HCID 923Sodium Ion2×

HCID 63651,1-Dichloroethane

HCID 19660Carbonate Ion

HCID 24613Phosphorus oxybromide

HCID 1785169094-(cyclopropylmethyl)-2-hydroxypyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 581031982-bromo-4-(cyclopropylmethyl)pyrido[2,3-b]pyrazin-3(4H)-one

Sources & evidence

ORD record: ord-cfc86518ca2e470eac8ad38852523a52
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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