Diglyme → HCID 178418794, compound

Reaction equation

[CH2:1]([O:3][C:4](=[O:11])[C:5]([N:7](C=O)[NH2:8])=[NH:6])[CH3:2].[CH3:12]OCCOCCOC>>[CH2:1]([O:3][C:4]([C:5]1[N:6]=[CH:12][NH:8][N:7]=1)=[O:11])[CH3:2]

Participants

Reactant 2

HCID 8150Diglyme

HCID 86590617(N-Formylhydrazino)-imino acetic acid ethyl ester

Product 1

HCID 178418794HCID 178418794, compoundYield 85%

Procedure

A suspension of (N-Formylhydrazino)-imino acetic acid ethyl ester (9.62 g, 60.4 mmol) in diglyme (40 ml) was refluxed for 30 minutes. After cooling, the precipitated crystal was collected by filteration and washed with hexane to give 1H-1,2,4-triazol-3-carboxylic acid ethyl ester (7.28 g). Yield: 85%.

Workup

temperaturewas refluxed for 30 minutes
temperatureAfter cooling
customthe precipitated crystal was collected by filteration
washwashed with hexane

Sources & evidence

ORD record: ord-4b7b68e3c87e41339a24a58d40a683c6
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07098201B2

Reaction notes

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