Decanoyl chloride → 2-(decanoylamino)propanoic Acid

Reaction equation

Cl.C[O:3][C:4](=[O:8])[CH:5]([CH3:7])[NH2:6].[C:9](Cl)(=[O:19])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>>[C:9]([NH:6][CH:5]([CH3:7])[C:4]([OH:3])=[O:8])(=[O:19])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

Reactant 2

HCID 66982Decanoyl chloride

HCID 2756298Alanine, methyl ester, hydrochloride (1:1)

Product 1

HCID 42026322-(decanoylamino)propanoic Acid

Procedure

The preparation is carried out analogously to the procedure of example 4A using 19.0 g (184 mmol) of D,L-alanine methyl ester hydrochloride and 35.14 g (184 mmol) of decanoyl chloride.

Sources & evidence

ORD record: ord-6ee13a8e601e4d21be3558a4c3597e8a
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07098207B2

Reaction notes

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