Methanol → 2-chloro-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

HRID 1129343

Reaction equation

HRID 1129343 reaction equation
[CH2:1]([C:2]#[CH:3])[O:4][c:5]1[cH:6][cH:7][c:8]([NH2:9])[cH:10][cH:11]1.[CH3:21][OH:22].[CH3:24][CH2:25][O:26][C:27]([CH3:28])=[O:29].[Cl:12][c:13]1[n:14][cH:15][c:16]([F:20])[c:17]([Cl:19])[n:18]1.[OH2:23]>>[CH2:1]([C:2]#[CH:3])[O:4][c:5]1[cH:6][cH:7][c:8]([NH:9][c:17]2[c:16]([F:20])[cH:15][n:14][c:13]([Cl:12])[n:18]2)[cH:10][cH:11]1

Participants

6

Reactant 5

HCID 887MethanolHCID 962WaterHCID 8857Ethyl AcetateHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 126688624-(Prop-2-yn-1-yloxy)aniline

Product 1

HCID 575628992-chloro-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

Sources & evidence

ORD record
ord-127f492812fa4f6296a386c78fd8f327
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Linked notes

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