Tetrahydrofuran → (2,2-Difluoro-9-((4-(2-hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

HRID 1133846Notes

Reaction equation

HRID 1133846 reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:44](=[O:45])[c:46]4[n:47][c:48]([CH:51]([CH3:52])[CH3:53])[s:49][cH:50]4)[CH2:39][C:40]([F:42])([F:43])[O:41]3)[CH2:54][CH2:55]2)[s:30][cH:31]1)([CH3:23])([CH3:56])[CH3:57].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:58]1[O:59][CH2:60][CH2:61][CH2:62]1.[F-:1]>>[OH:24][CH2:25][CH2:26][c:27]1[cH:28][c:29]([CH2:32][N:33]2[CH2:34][CH2:35][C:36]3([CH2:37][N:38]([C:44](=[O:45])[c:46]4[n:47][c:48]([CH:51]([CH3:52])[CH3:53])[s:49][cH:50]4)[CH2:39][C:40]([F:42])([F:43])[O:41]3)[CH2:54][CH2:55]2)[s:30][cH:31]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 57989002(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-2,2-difluoro-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Product 1

HCID 57989282(2,2-Difluoro-9-((4-(2-hydroxyethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Sources & evidence

ORD record
ord-c7e59844a28a45f6abac19250f1f6b88
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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